This includes CDK6 [23], EVI-1 [24,25] and EYA1 [26,27], which are also found upregulated in MLLr leukaemias as a result of direct binding of MLL-FPG proteins to gene promoters [26,28,29], and play a vital role in leukaemic transformation including cellular immortalization [26], hyperproliferation [23,24], chemoresistance [24] and dysregulated self-renewal [25,27]. The gene discussed is KMT2A; the disease is leukemia.