CDK6 and neoplasm: The miR-15a/16-1 cluster directly down-regulates the anti-apoptotic protein BCL-2, MCL-1, CCND1, and WNT3A [91] and leads to induction of G0G1 arrest in tumor cells by suppressing cell cycle-positive regulators including CDK6 (Cyclin Dependent Kinase 6), Cyclins D and E [92].