Notably, BMI-1 has been one of the first genes initially identified as an oncogene that cooperates with MYC in the generation of mouse pre-B-cell lymphomas by inhibiting INK4a/ARF proteins and by activating the human telomerase reverse transcriptase (h-TERT) [60]. The gene discussed is CDKN2A; the disease is B-cell non-Hodgkin lymphoma.