In parallel, other studies have shown that, with increased age (> 70 years), the risk of venous thrombosis was 2.2-fold greater in factor V Leiden carriers, 1.4-fold greater in prothrombin G20210A mutation carriers, 1.3-fold greater in those with non-O blood group, and 2.1-fold greater in those with a positive family history of venous thrombosis [216]. The gene discussed is F2; the disease is Venous thrombosis.