The role of arachidonic acid-derived prostanoids and leukotrienes on lung fibrosis have been dealt with in the earlier section and here we will review the recent developments on fatty acid, PLD/PA, ATX/LPA, cardiolipin metabolism by lysocardiolipin acyltransferase (LYCAT) and oxidized phospholipids in the pathophysiology of lung fibrosis. The gene discussed is LCLAT1; the disease is pulmonary fibrosis.