There are six isoforms of PLD, PLD1-6, of which PLD1 and PLD2 isoforms exhibit the ability to hydrolyze phospholipids and these two isoforms have been widely recognized in several human pathophysiologies including cancer, hypertension, neurodisorders, diabetes, and acute lung injury [228,229,230,231]. The gene discussed is PLD1; the disease is diabetes mellitus.