In prostate cancer cells, ZEB1 plays dual functions in order to repress E-cadherin and at the same time activates Vimentin by recruiting SET8 (a histone H4K20-specific methyl transferase) to E-cadherin promoter and activate a ZEB1-dependent H4K20 monomethylation, respectively [85]. This evidence concerns the gene CDH1 and Familial prostate cancer.