Notably, expression of USP4 was also significantly correlated with expression of Oct4 (R = 0.295; p < 0.001; n = 203) and Sox2 (R = 0.448; p < 0.001; n = 203), suggesting that USP4 is a potential positive regulator of lung cancer stemness. This evidence concerns the gene POU5F1 and lung carcinoma.