In the context of diet-induced obese mice bearing melanoma, CPT1A is also upregulated in CD8+ T cells in association with other biomarkers of T cell exhaustion, and this appears to be mediated via leptin signaling as administration of leptin to leptin-deficient mice was sufficient to induce CPT1A expression in CD8+ T cell populations [21]. This evidence concerns the gene CPT1A and melanoma.