Clinical evidence of a role for lipid uptake in melanoma progression comes from analysis of the Cancer Genome Atlas (TCGA) melanoma patients, whereby Nath and Chan identified a gene signature that included fatty acid uptake genes caveolin-1 (CAV1) and cluster of differentiation 36 (CD36), and the fatty acid oxidation gene carnitine palmitoyltransferase 1C (CPT1C), that predicts significantly worse overall survival in melanomas enriched for this signature [52]. This evidence concerns the gene CPT1C and melanoma.