Compounds 98, 100 and 101 exhibited significant cytotoxicity against five human cancer cell lines, i.e., CNE1 (nasopharyngeal carcinoma), CNE2 (nasopharyngeal carcinoma), HONE1 (nasopharyngeal carcinoma), SUNE1 (spectrin repeat containing nuclear envelope protein 1), GLC82 (lung carcinoma) cancer cell lines as well as HL7702 (normal hepatic) cells [42]. Here, SYNE1 is linked to cancer.