HSPA1A and prion disease: Additional genes that were predicted targets only to the down-regulated miRNAs (targets stimulated), included members of the complement membrane attack complex (C6 and C8g), a component of the innate immune system that correlates with neuropathological lesions in sCJD brains [55], a heat shock protein with protective role in prion disease (Hspa1a) [56], and a proinflammatory cytokine increased in patients with sCJD (Il6) [57].