The up/down miRNA datasets overlapped with regard to subset of target mRNAs that included genes involved in endoplasmic reticulum stress (Casp12) [52], modulation of astrocyte activation in murine scrapie model (Il1) [53], as well as cellular prion protein (PrPC)-associated lipid raft component (Fyn) [54] and Prnp itself. The gene discussed is FYN; the disease is scrapie.