CYLD and Brooke-Spiegler syndrome: Examples of these deregulations include the BRCA1-associated protein 1 (BAP1) of the UCH family of DUBs, which is commonly mutated in mesotheliomas, melanomas, and renal cell carcinomas [31]; USP6 translocation in aneurysmal bone cysts [32]; USP9X mutations that cause developmental disorders and deregulated expression in cancer [33,34]; USP15 overexpression in certain glioblastomas, ovarian cancer, and breast cancer [35]; and cylindromatosis (CYLD) mutations in familial cylindromatosis [36].