Various proteins have been implicated in the processing of the synapses, such as SNAP-25 (synaptosomal-associated protein of 25), PSD-95 (postsynaptic density protein 95), synapsin 1 and chromogranin B (synaptic vesicle proteins), all of which are reduced in AD brain [60,61]. The gene discussed is SNAP25; the disease is Alzheimer disease.