Nine genes are associated with CPVT (Figure 1), and genetic alteration (noncommon variants and CNV) is a potential cause in almost 65% of cases, although 60% of cases are attributed to rare nonsynonymous variants in the cardiac ryanodine receptor (RYR2) [20]. The gene discussed is RYR2; the disease is catecholaminergic polymorphic ventricular tachycardia.