An Italian family with familial hemiplegic migraine (FHM) with the absence of mutations in the known genes associated with this disorder, namely <i>ATP1A2</i>, <i>ATP1A3</i>, <i>CACNA1A</i>, and <i>SCN1A</i>, has recently been reported. The gene discussed is ATP1A2; the disease is familial hemiplegic migraine.