LMNA and Emery-Dreifuss muscular dystrophy: Using RNA-sequencing technology on Lmna-/- mice, Auguste and colleagues showed that the FOXO signaling pathway impacted different signaling pathways, i.e., NFκB, TNFα, P53 and OxPHOS signaling pathways and biological processes, i.e., apoptosis, sustaining the cardiac phenotype associated with EDMD [49].