SLC5A2 and diabetes mellitus: However, it must be highlighted that the traditional framework about the effect of SGLT2iarises from several experimental (murine) models showing that SGLT2 inhibition elicits renal hemodynamic changes that attenuate glomerular hyperfiltration, thus demonstrating the important role of tubulo-glomerular feedback in early renal hemodynamic abnormalities diabetes related and lowers urine albumin excretion [17,18,19].