Using overlapping peptides spanning the DENV2 proteome, the T-cell response in Thai paediatric dengue patients was shown to be directed to NS3 most frequently, followed by NS5, E, and NS1 [34], while in adult dengue patients from Singapore, CD8+ T-cell responses were mainly directed to NS3 and NS5, and CD4+ T-cell responses to the C and E proteins and to a lesser extent to NS1 [340]. This evidence concerns the gene CD4 and dengue disease.