One of the most important factors in hepatocarcinogenesis is the modulation of developmental and oncogenic signaling pathways involved in the pathogenesis of HCC, such as the key signal transduction pathways Wnt/β-catenin, EGFR-RAS-MAPKK, c-MET, IGF signaling, Akt/mTOR signaling, and VEGF and PDGFR signaling cascades [76]. This evidence concerns the gene EGFR and hepatocellular carcinoma.