Furthermore, in ALICE-1 study, SNPs analysis of VEGFA, VEGFC, and VEGFR-1,2,3 from 148 samples receiving sorafenib showed that VEGFA allele C of rs2010963 and VEGFC allele T of rs4604006 together with Barcellona Clinic Liver Cancer (BCLC) stage were independent factors influencing progression-free survival (PFS) and overall survival (OS) of HCC patients. The gene discussed is VEGFC; the disease is hepatocellular carcinoma.