Presence of High risk PCa factors–PSA >20–PSA-DT doubling time < 6 months–T3 disease, and/or local or systemic symptomsBiopsy must be delayed up to 3 months ( 8 ).Absence of High risk PCa factorsBiopsy may be postponed 3 to 6 months ( 8 ). Here, KLK3 is linked to posterior cortical atrophy.