Approximately 40% of patients present with high-risk neuroblastoma (HRN), which arises in older children, harbors several unfavorable genetic alterations (MYCN amplification, structural chromosome aberrations with gains and losses especially in 1p, 11q, and 17q), and is usually metastatic, mainly to bone and bone marrow (1, 2). The gene discussed is MYCN; the disease is neuroblastoma.