Besides, we conceived that AS might up‐regulate the expression of ADCY family to activate the cAMP and Rap1 signalling pathway assisted by A2AR to attenuate BLM‐induced pulmonary fibrosis; however, further in vivo and in vitro experiments are needed to investigate the specific functions of ADCY family and their detailed mechanism in the treatment of AS in pulmonary fibrosis. The gene discussed is ADORA2A; the disease is pulmonary fibrosis.