Finally, the expressions of those hub genes were still dramatically decreased with the treatment of AS in A2AR‐/‐ mice (KOAS vs BLM + AS group), suggesting that A2AR, as involved in ADCYs‐cAMP‐Rap1 pathways, might play a potential role in the therapeutic effect of AS on bleomycin‐induced pulmonary fibrosis. Here, ADORA2A is linked to Bloom syndrome.