Hyperglycemia can cause myocardial oxidative stress, activate a large number of cytokines, regulate myocardial cell function and apoptosis through AKT pathway,29 enhance PI3K activity to prevent cardiac remodelling, protect cardiac function in diabetic mice, and inhibit PI3K activity, which can accelerate the occurrence of DCM.30 This evidence concerns the gene AKT1 and familial dilated cardiomyopathy.