Human clinical studies have shown that placental expression and/or maternal serum levels of many growth factors, including VEGF, IGF-I, EGF, HB-EGF, TGFβ, soluble endoglin, and other peptides, as well as Notch-2, endothelial colony-forming cells, tyrosine kinase-like orphan receptor, and microRNA-93, are either elevated, decreased, or unaltered in mid to late gestation in women who develop preeclampsia [23, 26, 60–70]. The gene discussed is NOTCH2; the disease is preeclampsia.