The predictive value of KRAS mutation in NSCLC was investigated in the metastatic setting in patients receiving definitive chemotherapy [39], in patients receiving adjuvant chemotherapy with radiation after surgery [40], and also in the phase III TRIBUTE trial where first-line carboplatin/paclitaxel plus erlotinib or placebo was compared in advanced-stage NSCLC [41]. This evidence concerns the gene KRAS and non-small cell lung carcinoma.