IFNG and neoplasm: More specifically, cytokines such as IL-1B, interleukin 6 (IL-6), interferon gamma (IFN-γ) and interleukin 10 (IL-10) can effectively activate immunosuppressive pathways in myeloid-derived suppressive cells (MDSCs) and induce the differentiation of MDSCs into tumor-protective dendritic and macrophage cells (Dysthe and Parihar, 2020).