In a cohort study of 2901 Swedish men (including 589 incident cardiovascular events), both high (>80th percentile) and low (<20th percentile) IGF-1 levels were associated with increased risk of any cardiovascular event, and high but not low IGF-1 levels were associated with a statistically significant higher risk of coronary artery disease [12]. Here, IGF1 is linked to coronary artery disorder.