IGF1 and myocardial infarction: Similarly, in a nested case–control study of US women (245 myocardial infarction cases and 490 matched controls), the multivariable-adjusted RR (95% CI) of myocardial infarction was 2.09 (1.17, 3.72) and 1.46 (0.79, 2.72) for the third and fourth highest quartile of IGF-1 levels, respectively, when compared with the bottom quartile [8].