Another functional driver of melanoma aggressiveness features through a common molecular role in tumor growth, maintenance, and drug resistance is exerted by the cell membrane-associated transporter ABCB5 (ATP-binding cassette sub-family B member 5, also known as P-glycoprotein) (Frank et al., 2005; Schatton et al., 2008). This evidence concerns the gene ABCB5 and neoplasm.