TGM2 and Abnormal intestine morphology: Intestinal anti-TG2 antibodies can be considered to be relevant from a clinical viewpoint for two reasons: the first is their supposed capability to predict the development of a full blown enteropathy in a early phase disease condition such as potential celiac disease; the second is their possible role in revealing a condition of gluten reactivity in patients with absence of circulating CD-associated autoantibodies.