The survival analysis showed that upregulation of 6 mRNAs (ANLN, TOB1, AURKA, MELK, KIF23, and CHEK1), 3 miRNAs (miR-135b-5p, miR-424-5p, and miR-203a-3p) and 4 lncRNAs (AL049555.1, LINC00941, LINC01588, and CASC8) was associated with poor PAAD OS, while down regulation of the remaining 6 genes (GOLAG8B, miR-129-5p, MIR600HG, AL365277.1, AC005674.2, and AP004608.1) in PAAD indicated a longer survival time. The gene discussed is MELK; the disease is pancreatic adenocarcinoma.