In our study, WGCNA was used to identify the green module (involving 85 genes) that was related to PAAD OS, and 4 genes (AURKA, MELK, KIF23, and CHEK1) were found specifically expressed in PAAD and played an important role in the development of PAAD, which may become the prognostic markers. This evidence concerns the gene AURKA and pancreatic adenocarcinoma.