Several studies, including candidate-gene identification and genome-wide association studies (GWAS), have identified different genetic loci that are likely contributing to the development of EoE and mainly include thymic stromal lymphopoietin (TSLP), calpain 14 (CAPN14), EMSY, LRRC32, STAT6, and ANKRD27 (7). The gene discussed is ANKRD27; the disease is eosinophilic esophagitis.