Based on this, we aimed to detect the levels of plasma adipocytokines including APN, TNF-α, IL-6, and PAI-1 in patients with intracranial and extracranial arteriosclerosis, and to observe whether there are differences in plasma APN, TNF-α, IL-6, and PAI-1 levels between intracranial and extracranial arteriosclerosis with different degrees of stenosis, then to further explore whether there is a correlation between intracranial and extracranial arteriosclerosis and the above adipocytokines. This evidence concerns the gene ANPEP and arteriosclerosis disorder.