NLRP3 and infection: However, since IAV infection activates pyroptosis through the NLRP3 (nucleotide-binding oligomerization domain-like receptor [NLR] family pyrin domain-containing 3) inflammasome (Kanneganti et al., 2006a,b) and CASP8 has been shown to regulate NLRP3 inflammasome activation (Gurung et al., 2014), we have seen that pyroptosis is also blocked after this infection in the Ripk3−/−Casp8−/− BMDMs (Zheng et al., 2020).