In mice mimicking human ABPA, intranasal treatment with native SP-D (or rfhSP-D) suppressed A. fumigatus allergen-specific IgE levels, eosinophilia, pulmonary cellular infiltration and switched the cytokine profile from a pathogenic Th2 to a protective Th1 (Madan et al., 2001). The gene discussed is SFTPD; the disease is Increased total eosinophil count.