Other genes, such as C5, CD4, CETP, COL18A1, DAND5, DNASE1, EBPL, F7, FLT3, ITGB2, KNG1, LMOD1, PPAT, PPIA, PRF1, SELP, SPPL2A, and TRPV1 that have not been systematically reported in relation to the prognosis of liver cancer, are our newly discovered prognostic markers for DFS in liver cancer. Here, SPPL2A is linked to liver cancer.