Among the 930 combinations and 31 combinations mentioned above, the diagrams and tables of the OS-related survival analyses of the top 15 combinations with the smallest p-values and the single genes they contain are as follows (Figures 4, 5; Tables 3, 4) Among the 12 genes that have an unknown association with HCC prognosis, F2, GOT2, TRPV1, and their combination F2-GOT2-TRPV1 were all significantly associated with OS in 370 liver cancer samples from the TCGA data (F2: p = 0.005; GOT2: p < 0.001; TRPV1: p = 0.002; F2-GOT2-TRPV1: p < 0.001). The gene discussed is GOT2; the disease is hepatocellular carcinoma.