The results of IHC for 90 liver cancer cases showed that the low protein expression of F2, GOT2, and TRPV1 was significantly associated with lower 5-year survival in HCC patients (F2: p = 0.033, GOT2: p = 0.035, TRPV1: p = 0.046; K-M survival analyses). This evidence concerns the gene TRPV1 and liver cancer.