The OS-related multivariate analysis results showed that the expression of 28 genes (ABCC1, ANXA7, APOB, ATG7, BAK1, CA9, CCNA2, CHD1L, CYP3A4, E2F1, EZH2, F2, G6PC, GMPS, GOT2, HDAC2, HPX, KPNA2, LAPTM4B, MAGEB3, MAPT, MPV17, NTF3, PPAT, SLC2A1, SLC38A1, SPP1, and TRPV1) was significantly associated with OS in HCC patients. The gene discussed is CHD1L; the disease is hepatocellular carcinoma.