The OS-related multivariate analysis results showed that the expression of 28 genes (ABCC1, ANXA7, APOB, ATG7, BAK1, CA9, CCNA2, CHD1L, CYP3A4, E2F1, EZH2, F2, G6PC, GMPS, GOT2, HDAC2, HPX, KPNA2, LAPTM4B, MAGEB3, MAPT, MPV17, NTF3, PPAT, SLC2A1, SLC38A1, SPP1, and TRPV1) was significantly associated with OS in HCC patients. Here, MPV17 is linked to hepatocellular carcinoma.