WNK2 and cancer: Figure 2C shows the top 15 enriched pathways according to adjusted P-value. Altered signaling pathways included some well-reported cancer-associated pathways, such as PI3K-Akt (adjusted P = 0.0006), mitogen-activated protein kinase (MAPK) (adjusted P = 0.002), Ras (adjusted P = 0.007), and Wnt (adjusted P = 0.003) signaling pathways, and covered focal adhesion (adjusted P = 0.003), and cell adhesion molecules (adjusted P = 0.0002).