CKB and colorectal carcinoma: MiR-551a and miR-483 suppress hepatic colonization and metastasis of CRC cells by convergently dysregulating creatine kinase brain-type (CKB), which is released into the extracellular microenvironments by hypoxic metastatic cells and catalyzes the production of phosphocreatine that helps to generate ATP and fuel metastatic cells (21).