The expression of miR-485 is downregulated in breast cancer tissues and the overexpression of its both mature forms, miR-485-3p and miR-485-5p, restrains mitochondrial respiration and suppresses the metastasis of breast cancer cells by downregulating peroxisome proliferator-activated receptor-gamma coactivator (PGC)−1α (84). This evidence concerns the gene PPARGC1A and breast cancer.