The direct interaction of PKM2 in the nucleus with TGF (transforming growth factor)-β-induced factor homeobox 2 (TGIF2), leading to the recruitment of histone deacetylase 3 to the E-cadherin promoter sequence, with subsequent deacetylation of histone H3 and suppression of E-cadherin transcription, thus promoting the process of epithelial-mesenchymal transition (EMT) in colon cancer cells (71). Here, CDH1 is linked to malignant colon neoplasm.