PFKFB2 and cancer: In ovarian cancer, the chemokine CXCL14 (C-X-C motif ligand 14)-high expressed cancer-associated fibroblasts mediate the upregulation of lncRNA LINC00092, which downregulates PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2), a glycolytic enzyme involved in synthesis and degradation of fructose-2,6-bisphosphate, thereby promoting metastasis by altering glycolysis (47).