TUG1 and hepatocellular carcinoma: Knockdown of lncRNA-TUG1 induces a marked inhibition of cell migration, invasion, and glycolysis by suppressing miR-455-3p, which is transcriptionally repressed by p21 and directly targets the 3′-UTR of adenosine monophosphate-activated protein kinase subunit β2 (AMPKβ2), thus the lncRNA TUG1/miR-455-3p/AMPKβ2 axis regulates the metastasis and glycolysis of HCC cells through the regulation of HK2 (40).