HOXA9 and cutaneous squamous cell carcinoma: For example, miR-365 directly targets homeobox A9 (HOXA9) by binding to 3′-UTR region, and the downregulation of HOXA9 increases the expression of HIF-1α and its downstream glycolytic genes HK2, GLUT1, and PDK1, promoting glycolysis and metastasis of cutaneous squamous cell carcinoma (114).