In addition, CUX1 was enriched in tumor-associated macrophages (TAMs) and interacted with nuclear factor κB (NF-κB) p65 to attenuate the activation of NF-κB signaling, leading to a decrease in T-cell attraction and an increase in angiogenesis in pancreatic cancer (80). Here, CUX1 is linked to familial pancreatic carcinoma.