TP53 and breast carcinoma: In addition, SERPINA5 has been identified to be more highly methylated in HR-, basal-like, or p53 mutant breast cancer than HR+, luminal A, or p53 wild-type breast cancers, and gene signature composed of SERPINA5 and 3 other genes can predict the prognosis of patients with stage I LUAD (Conway et al., 2014; Luo, Wang & Zhang, 2018).