PTEN and nonpapillary renal cell carcinoma: In addition, in 446 ccRCC cases, integrative proteogenomic analysis revealed that some members of the PI3K/AKT/mTOR signaling pathway, for example, PTEN and AKT mRNA expression levels, and PTEN protein expression levels, were recognized as favorable predictors for ccRCC (Cancer Genome Atlas Research N, 2013), which was also consistent with our findings in the present study.