The RNA-Seq data from TCGA and GTEx were used to compare the expression levels of nine PI3K/AKT/mTOR signaling pathway members (PTEN, PIK3CA, PIK3CB, PIK3CD, PIK3CG, AKT1, AKT2, AKT3 and mTOR) between ccRCC and normal kidney tissues. This evidence concerns the gene PTEN and nonpapillary renal cell carcinoma.