It was observed that PTEN, PIK3CA and PIK3CB were positively correlated with a favorable OS in stage I, III and IV patients with ccRCC [HR 95% CI = 0.46 (0.25–0.85) (stage I); 0.44 (0.25–0.79) (stage III); 0.51 (0.30–0.87) (stage IV) for PTEN; 0.48 (0.26–0.88) (stage I); 0.51 (0.29–0.89) (stage III); 0.61 (0.37–1.00) (stage IV) for PIK3CA; and 0.43 (0.23–0.81) (stage I); 0.40 (0.22–0.70) (stage III); 0.41 (0.25–0.67) (stage IV) for PIK3CB, respectively]. This evidence concerns the gene PIK3CA and nonpapillary renal cell carcinoma.