Integrated bioinformatics analysis confirmed that the PI3K/AKT/mTOR pathway was activated in ccRCC, but the prognostic significance was not fully elucidated (Cancer Genome Atlas Research N, 2013; Chen et al., 2016; Han et al., 2017; Zhang et al., 2017). The gene discussed is PIK3CA; the disease is nonpapillary renal cell carcinoma.