The RNA-Seq data from TCGA and GTEx were used to compare the expression levels of nine PI3K/AKT/mTOR signaling pathway members (PTEN, PIK3CA, PIK3CB, PIK3CD, PIK3CG, AKT1, AKT2, AKT3 and mTOR) between ccRCC and normal kidney tissues. The gene discussed is PIK3CD; the disease is nonpapillary renal cell carcinoma.