PIK3CA and nonpapillary renal cell carcinoma: In the present study, the mRNA and some protein expression profiles of PI3K/AKT/mTOR signaling pathway members were compared between ccRCC and normal kidney tissues using the GEPIA, Oncomine and western blotting (WB) analyses, and their prognostic significance in ccRCC was subsequently systematically analyzed using the K-M plotter, HPA and TCPA databases (Fig. 1).