When striatified by clinical stage of the 523 ccRCC cases using GEPIA, the mRNA expression levels of six genes, i.e., PTEN, PIK3CA, PIK3CB, AKT1, AKT2 and AKT3, were negatively correlated with their stages (P < 0.05). Here, PTEN is linked to nonpapillary renal cell carcinoma.