The present study investigated the mRNA expression profiles of multiple PI3K/AKT/mTOR signaling pathway components, including PTEN, PIK3CA, PIK3CB, PIK3CD, PIK3CG, AKT1, AKT2, AKT2 and mTOR, in ccRCC and normal tissues using GEPIA and Oncomine analyses, and detected PI3K, AKT and mTOR protein expression using WB analysis. The gene discussed is AKT2; the disease is nonpapillary renal cell carcinoma.