Further prognostic analysis using the K-M plotter and HPA demonstrated that the mRNA expression levels of the major PI3K/AKT/mTOR signaling pathway members (PTEN, PIK3CA, PIK3CB, PIK3CG, AKT3 and mTOR) were positively correlated with a favorable OS in patients with ccRCC, whereas PIK3CD mRNA expression levels were positively correlated with a poor OS (P < 0.05). This evidence concerns the gene PTEN and nonpapillary renal cell carcinoma.