These homing ligands are attached to the surface of NPs, which then enable the active binding of the nanocarrier PS conjugate to overexpressed cancer cell receptors, such as epidermal growth factor receptors (EGFR), folate receptors (FR), transferrin-receptors (TfR), CD44 or CD22, to enhance overall PS cellular uptake and localization [61]. The gene discussed is EGFR; the disease is cancer.