In another study anti HER-2 antibody, indocyanine green (ICG) and doxorubicin (DOX) were loaded onto polyethyleneimine (PEI)-coated perfluorocarbon double nanoemulsions (HIDPPDNEs) for the targeted photochemotherapy of HER-2 positive MDA-MB-453 breast cancer cells [78]. Here, ERBB2 is linked to breast carcinoma.