The application of copolymers was extended using two FDA-approved polymers in studies performed by Lee et al., to fabricate anti-HER-2 indocyanine green (ICG) - doxorubicin (DOX) - encapsulated polyethylene glycol (PEG)-poly(lactic-co-glycolic acid) (PLGA) diblock (PEG-b-PLGA) copolymeric NPs (HIDPPNPs) for the phototherapy and chemotherapy of HER-2-overexpressing breast cancer cells [88]. This evidence concerns the gene ERBB2 and breast cancer.