The lymphoid phosphatase (LYP), a cytosolic protein tyrosine phosphatase encoded by the PTPN22 gene, has been shown to be overexpressed in CLL cells and positively regulates AKT signal downstream of BCR, at least in part, by reducing recruitment and activation of SHIP to the BCR [16]. The gene discussed is BCR; the disease is B-cell chronic lymphocytic leukemia.