Furthermore, the correlation analysis between lnc-TRDMT1-5 expression and the clinicopathological characteristics illustrated that lnc-TRDMT1-5 levels were significantly increased in ER-positive and HER2-positive BC patients (Table 2) and that lnc-TRDMT1-5 expression may be potentially related to TNM stage and the level of Ki67 positivity (P = 0.051). The gene discussed is ESR1; the disease is breast cancer.