Furthermore, KEGG pathway analysis indicated that upregulated mRNAs were enriched in cancer-related pathways, such as focal adhesion and the PI3K/AKT signaling pathway (Figure 1G), while downregulated mRNAs were enriched in resistance-related pathways, such as endocrine resistance and the mTOR signaling pathway (Figure 1H). The gene discussed is AKT1; the disease is cancer.