Furthermore, we found that these DE-mRNAs were involved in transcript regulation, and the phosphoinositide 3-kinase (PI3K)/Akt/mTOR signaling pathway, both of which play important roles in BC tumorigenesis (Guerrero-Zotano et al., 2016), progression, and chemoresistance (Okada et al., 2015). The gene discussed is AKT1; the disease is breast cancer.