KDR and cancer: Also, many targeted genes, such as ZEB1, SOX5, AKAP1, CHP1, CNBP, VEGFR, and MAGT1, play a vital function in the cell shape, movement, invasion, adhesion, and polarity formation, so as to involve in many kinds of diseases such as malignant tumors, wound healing, and so on (Rinaldi et al., 2017; Caramel et al., 2018; Hu et al., 2018).