Moreover, the expression of MBD4 mRNA showed an inverse correlation with DNA methylation in CD4+ T cells from SLE patients (144), and a positive correlation with the overexpression of costimulatory genes such as CD40LG, TNFSF7, ITGAL, PRF1, and KIR2DL4 (145). Here, CD4 is linked to systemic lupus erythematosus.