Indications that APE2 is directly involved in other B-cell neoplasms or in autoimmune diseases have not been reported, but it's evident association with CSR and SHM indicate that APE2 has a role in genomic alterations in B-cell lymphomas and aberrant clonal selection in autoantibody-mediated diseases. Here, APEX2 is linked to B-cell non-Hodgkin lymphoma.