MSH2 and diffuse large B-cell lymphoma: In contrast, UNG deficiency was shown to be protective for the development of BCL6-driven mouse diffuse large B-cell lymphomas (DLBCL), whereas MSH2 deficiency or the combined deficiency of UNG and MSH2 accelerated lymphomagenesis, accompanied by the accumulation of AID-dependent mutations in non-Ig target genes (76).