However, the established relation between B-cell lymphomas and CSR-mediated chromosomal translocations (214), and the function of APE1 therein, suggest that APE1 functions as a crucial mediator of DSBs downstream of AID, which when repaired illegitimately lead to lymphoma-associated genomic lesions. The gene discussed is AICDA; the disease is B-cell non-Hodgkin lymphoma.