Other in vitro and in vivo studies that support the involvement of TDG in cancer showed that TDG regulates the expression of tumor suppressor genes by interacting with several transcription factors, including the retinoic acid receptor (RARa), retinoid X receptor (RXR), estrogen receptor α (ERα), thyroid transcription factor 1 (TTF1), and histone acetyl-transferases p300 and CBP (103, 107–109). This evidence concerns the gene ESR1 and neoplasm.