Functionally, apoptotic Treg cells are more efficient than live cells in downregulating the expression of IFN-γ, TNF-α, and IL-2 by tumoricidal T cells (47), while the pre-existence of apoptotic Treg cells in CRC tumors potentially distorts the therapeutic efficacies of immune checkpoint inhibitors (47). This evidence concerns the gene IFNG and colorectal carcinoma.