Based on the ability of the T cell subsets, including Th1, cytotoxic T, and memory T cells, to cause tumor shrinkage, the densities of CD3+CD45RO+ memory T cells and CD3+CD8+ cytotoxic T cells either in the tumor center (CT) or in the tumor invasive margin (IM) were included into this system (9). This evidence concerns the gene CD8A and neoplasm.