IL10 and infectious disease: However, recent reports have shown that IL-35-producing B cells (i35-Bregs) regulate immunity during CNS autoimmune diseases by inducing expansion of IL-10-producing Bregs (B10), IL-10-producing T cells (Tregs), and IL-35-producing T cells (iTR35) (7–9), suggesting that i35-Bregs can be exploited in treating autoimmune or infectious diseases.