CXCL11 and autoimmune disease: C57BL/6 mice that lack functional CXCL11 due to a shift in the open reading frame of the CXCL11-encoding gene (insertion of two bases after nucleotide 39), resulting in the translation of a chimeric protein lacking the critical CXC motif (24), preferentially induce Th1 oriented response, are highly susceptible to the induction of various Th1-related autoimmune diseases.