(2) lnc-ITSN1-2 promoted IBD CD4+ T cell activation, proliferation, and stimulated Th1/Th17 cell differentiation (validate in our followed in vitro experiments), resulting in increased inflammation, thus lnc-ITSN1-2 was upregulated and positively correlated with disease activity and inflammation indexes in IBD patients. The gene discussed is ITSN1; the disease is inflammatory bowel disease.