Considering that lnc-ITSN1-2 was one of the most dysregulated DELs in IBD patients compared to HCs by RNA sequencing in our study, and because it is also reported to be implicated in development and progression of RA (15), a potential biomarker for coronary artery disease risk (although lacks significance, but presents with a trend) (16), we hypothesized that lnc-ITSN1-2 might be involved in IBD pathogenesis. This evidence concerns the gene ITSN1 and coronary artery disorder.