IFN-γ, TNF-α, IL-17, T-bet, and RORC expressions in IBD CD4+ T cells were all increased in the LV-lnc-ITSN1-2 group while decreased in the LV-anti-lnc-ITSN1-2 group compared to the LV-scramble group (Figures 12A–E). Here, CD4 is linked to inflammatory bowel disease.