In conclusion, lncRNA expression profiles play critical roles in the pathogenesis of IBD, and lnc-ITSN1-2 correlates with increased disease risk, activity, and inflammatory cytokines of IBD, and also promotes IBD CD4+ T cell activation, proliferation, and Th1/Th17 cell differentiation by serving as a ceRNA for IL-23R via sponging miR-125a. Here, CD4 is linked to inflammatory bowel disease.