Then rescue experiments showed that IL-23R knockdown decreased CD25+ cell percentage, CD69+ cell percentage, cell proliferation, and IFN-γ, TNF-α, IL-17, and T-bet as well as RORC expressions in miR-125a knockdown treated IBD CD4+ T cells (Supplementary Figures 6B–M). The gene discussed is CD4; the disease is inflammatory bowel disease.