ITSN1 and inflammatory bowel disease: Our bioinformatics analysis of RNA sequencing revealed that IL-23R was a key gene regulated by lnc-ITSN1-2 in IBD (Figure 1E), and IL-23R was one of the critical genes implicated in the etiology of IBD (20), thus, we hypothesized that lnc-ITSN1-2 might be involved in IBD pathogenesis via IL-23R.