Our bioinformatics analysis of RNA sequencing revealed that IL-23R was a key gene regulated by lnc-ITSN1-2 in IBD (Figure 1E), and IL-23R was positively correlated with lnc-ITSN1-2 in a large-sample validation by RT-qPCR (Figures 4F,L, 5F,L). The gene discussed is IL23R; the disease is inflammatory bowel disease.