Then we aimed to investigate the correlation of intestinal mucosa and PBMC lnc-ITSN1-2 expressions with disease risk, activity, and inflammation of IBD, and to further explore the effect of lnc-ITSN1-2 on regulating IBD CD4+ T cell activation, proliferation, and differentiation as well as its potential molecular mechanism. Here, ITSN1 is linked to inflammatory bowel disease.