Two previous studies observe that rheumatoid arthritis patients present with increased lnc-ITSN1-2 expression in blood and synovial tissue, along with a positive correlation with systemic inflammation (15, 27), which is partially in line with our results that lnc-ITSN1-2 was raised in IBD patients and correlated with higher systemic or lesion site inflammation. Here, ITSN1 is linked to inflammatory bowel disease.