ITSN1 and inflammatory bowel disease: We further analyzed IL-23R expression after lnc-ITSN1-2 lentivirus transfection in IBD CD4+ T cells, and found that IL-23R was upregulated in the LV-lnc-ITSN1-2 group while decreased in the LV-anti-lnc-ITSN1-2 group compared to the LV-scramble group (Figure 12F).