Based on target prediction using miRanda Database (www.microrna.org), and the anti-inflammation role of miR-125a as well as the pro-inflammation role of IL-23R, we further explored whether lnc-ITSN1-2 regulated the miR-125a/IL-23R pathway to regulate IBD CD4+ T cells. The gene discussed is ITSN1; the disease is inflammatory bowel disease.