Furthermore, referring to the target prediction using miRanda Database (www.microrna.org), and the ant-inflammation role of miR-125a, as well as the pro-inflammation role of IL-23R, we further explored whether lnc-ITSN1-2 regulated IL-23R via sponging miR-125a to regulate IBD CD4+ T cells functions, and these mechanism investigations observed that lnc-ITSN1-2 served as a ceRNA for IL-23R via sponging miR-125a, then regulated CD4+ T cell functions in IBD. Here, IL23R is linked to inflammatory bowel disease.