CD4 and inflammatory bowel disease: Furthermore, we observed that lnc-ITSN1-2 knockdown decreased the pJAK2, pSTAT3, IKKA, and NF-κB expressions in both CD and UC CD4+ T cells, while IL-23R overexpression improved the pJAK2, pSTAT3, IKKA, and NF-κB expressions in lnc-ITSN1-2 knockdown treated CD and UC CD4+ T cells (Supplementary Figures 4A,B), which indicated that the JAK2/STAT3 pathway and NF-κB pathway were regulated by lnc-ITSN1-2 through IL-23R in IBD CD4+ T cells.