CCR4 and hypercalcemia disease: For instance, elevated LDH levels, four total involved areas or more, thrombocytopenia, bone marrow involvement, eosinophilia, hypercalcemia, age of 40 or above, p53 mutations, p16 deletions, high IL-15 serum levels, and C-C chemokine receptor 4 (CCR4) expression are nowadays factors that predict poor prognosis (Tsukasaki et al., 2009).