HBZ and adult T-cell leukemia/lymphoma: Panobinostat, a HDACI, decreased in levels of factors involved in ATLL cell proliferation and invasion such as CCR4, IL-2R and HTLV-1 HBZ-SI, a spliced form of the HTLV-1 basic zipper factor HBZ, and induced apoptosis in ATL cells via activation of a novel RAIDD-caspase-2 pathway (Hasegawa et al., 2011).