CALCRL and myocardial infarction: The cardioprotective peptide adrenomedullin and its signaling partners Calcrl and RAMP2 critically regulate lymphangiogenesis during development or after myocardial infarction (Fritz-Six et al., 2008; Jin et al., 2008; Klein and Caron, 2015; Trincot et al., 2019), while Calcrl has been identified as an important upstream regulator of DLL4-Notch signaling (Davis et al., 2017).