Interleukin-6 (IL-6), IL-10 (Heim et al., 2015), and TNF (Xue et al., 2012) are important triggers of myeloid origin inhibiting the proliferation and recruitment of MDSCs and are considered to be the main coordinator of immunosuppressive tumor microenvironment (Zhang et al., 2018). Here, TNF is linked to neoplasm.